Computational Methods for Processing and Analysis of Biological Pathways

This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.

Anastasios Bezerianos is a Professor at the Medical School of Patras University, Greece. He is also a Senior Principal Research Fellow at the Singapore Institute for Neurotechnology (SINAPSE) within the Centre for Life Sciences (CeLS), a Research Professor in the Department of Electrical and Computer Engineering (ECE), and a member of the Faculty of NUS Graduate School (NGS) for Integrative Sciences and Engineering at the National University of Singapore (NUS). Andrei Dragomir is a Research Assistant Professor at the Department of Biomedical Engineering of the University of Houston, TX, USA. Panos Balomenos is a PhD Candidate at the Computer Engineering and Informatics Department of the University of Patras, Greece.